Innate response to Foamy viruses

The foamy viruses.

INTRODUCTION ........................................ 169 HISTORY ........................................ 170 CLASSIFICATION AND NOMENCLATURE .................................. 170 PROPERTIES OF VIRUSES ......... .......................... 170 Isolations and serological relationships ................................... 170 Morphology ........................................ 171 Physical and ch...

Evolution of Foamy Viruses:

Recent evidence indicates that foamy viruses (FVs) are the oldest retroviruses (RVs) that we know and coevolved with their hosts for several hundred million years. This coevolution may have contributed to the non-pathogenicity of FVs, an important factor in development of foamy viral vectors in gene therapy. However, various questions on the molecular evolution of FVs remain still unanswered. T...

Foamy viruses are unconventional retroviruses.

Antigenic relationship of human foamy virus to the simian foamy viruses.

A foamy virus isolated by Achong et al. from a human nasopharyngeal carcinoma was studied to determine its antigenic relationship to the eight known simiam foamy viruses (SFV). Using reciprocal cross-immunofluorescent and cross-neutralization techniques, we found the human isolate to be closely related to SFV type 6. In a seroepidemiological survey, neutralizing antibody to the human foamy viru...

Retrotransposition and cell-to-cell transfer of foamy viruses.

A remarkable feature of the prototype foamy virus (PFV) replication pathway has been reported to consist of the ability to retrotranspose intracellularly with high efficiency (M. Heinkelein, T. Pietschmann, G. Jármy, M. Dressler, H. Imrich, J. Thurow, D. Lindemann, M. Bock, A. Moebes, J. Roy, O. Herchenröder, and A. Rethwilm, EMBO J. 19:3436-3345, 2000). PFV intracellular retrotransposition (IR...